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Factor‐specific deactivation of leucocyte Chemotaxis in vivo
Author(s) -
Briheim Gunnar,
Stendahl Olle,
Dahlgren Claes
Publication year - 1986
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1986.tb02306.x
Subject(s) - chemotaxis , cerebrospinal fluid , in vivo , meningitis , immunology , peptide , chemistry , medicine , microbiology and biotechnology , biology , biochemistry , receptor , surgery
This report analyses the locomotory capacity of polymorphonuclear leucocytes (PMNL) isolated from 7 patients with bacterial meningitis. 7 healthy control subjects were also investigated in parallel. It was found that PMNL from the patients suffering from meningitis, isolated both from peripheral blood and from the cerebrospinal fluid, had lost their ability to respond chemotactically to activated serum but not to the chemotactic peptide f‐Met‐Leu‐Phe. The normal chemotactic responsiveness of blood PMNL was restored once the patients recovered from infection.