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Correlation between donor cytomegalovirus immunity and chronic graft‐versus‐host disease after allogeneic bone marrow transplantation
Author(s) -
Jacobsen Niels,
Andersen H. Kerzel,
Skinhøj Peter,
Ryder Lars P.,
Platz Per,
Jerne Donald,
Faber Viggo
Publication year - 1986
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1986.tb02287.x
Subject(s) - immunology , medicine , immune system , graft versus host disease , cytomegalovirus , immunity , pathogenesis , bone marrow , incidence (geometry) , transplantation , betaherpesvirinae , immunopathology , disease , viral disease , herpesviridae , virus , pathology , physics , optics
Chronic graft‐versus‐host disease (GvHD) in bone marrow allograft recipients is frequently preceded by a cytomegalovirus (CMV) infection. To elucidate whether an immune reaction of transplanted donor cells against CMV was involved in the pathogenesis of chronic GvHD, the effect of donor pretransplant CMV immune status on chronic GvHD incidence was analyzed. In 43 bone marrow recipients at risk, the 2‐yr cumulative chronic GvHD probability was 55% when the donor was immune, in contrast to 16.5% when the donor was non‐immune (p < 0.002). No correlation between recipient pretransplant CMV immunity and chronic GvHD was observed. Donor CMV immunity did not correlate with acute GvHD or posttransplant CMV infection and seemed to predispose for chronic GvHD regardless of donor and recipient age. However, the proportion of CMV immune donors increased with increasing donor and recipient age. This may account for the higher incidence of chronic GvHD in older patients. The present study suggests that chronic GvHD may be mediated by a reaction of immune donor cells against CMV infected recipient cells.