Premium
Expression of monocytic and T‐lymphocytic phenotype in a variant form of acute promyelocytc leukaemia (M3)
Author(s) -
Sato Tadashi,
Abe Rokuo,
Kawaguchi Michiko,
Uchida Tatsumi,
Kariyone Shigeo
Publication year - 1986
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1986.tb01789.x
Subject(s) - immunophenotyping , phenotype , monocyte , monocytic leukemia , chromosomal translocation , pathology , disseminated intravascular coagulation , population , precursor cell , immunology , biology , medicine , flow cytometry , cell , leukemia , gene , genetics , environmental health
A 46‐yr‐old woman was diagnosed as having M3 variant leukaemia in FAB sub‐classification with disseminated intravascular coagulation (DIC) and the 15;17 translocation. Immunologic examinations revealed that the blast cells exhibited monocytic (Ia +, Mo1 +, Mo2 +, My4 +, My7+ and My9 +) and T‐lymphocytic (OKT11 +, Leu4+ and Leu5b +) immunophenotype, with probably a biphenotypic population of cells. Expression of monocytic phenotype on the blast cells suggests that M3 variant includes a subtype with monocytic characteristics, and may be related to the morphologic monocyte‐like feature of that of M3 variant.