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Inhibition of erythropoiesis by human parvovirus‐containing serum from a patient with hereditary spherocytosis in aplastic crisis
Author(s) -
Takahashi Masuhiro,
Koike Tadashi,
Moriyama Yoshiaki,
Shibata Akira,
Koike Ryoko,
Sanada Masayoshi,
Tsukada Tsuneyasu
Publication year - 1986
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1986.tb01784.x
Subject(s) - hereditary spherocytosis , spherocytosis , aplastic anemia , parvovirus , immunology , medicine , hemolytic anemia , erythropoiesis , virology , anemia , virus , splenectomy , spleen , bone marrow
Aplastic phase serum from a patient with aplastic crisis of hereditary spherocytosis, which was demonstrated to contain human parvovirus, inhibited in vitro erythroid colony formation almost completely. Human parvovirus was resistant to heating for 30 min at 56°C. The suppressive effect of the serum was completely abrogated by adding convalescent phase serum from another patient with aplastic crisis of hereditary spherocytosis. Some normal sera had similar neutralizing ability. The results suggested that aplastic crisis of a patient with hereditary spherocytosis is caused by human parvovirus and that the neutralizing test could offer a tool for predicting the future occurrence of aplastic crisis in the patients with chronic hemolytic anemia.