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Platelet‐associated immunoglobulins IgG, IgM, IgA and complement C3c in chronic idiopathic autoimmune thrombocytopenia: relation to the sequestration pattern of 111 Indium labelled platelets
Author(s) -
Panzer Simon,
Niesser Herwig,
Lechner Klaus,
Dudczak Robert,
Jäger Ulrich,
Mayr Wolfgang R.
Publication year - 1986
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1986.tb01780.x
Subject(s) - platelet , antibody , immunology , spleen , medicine
Levels of platelet‐associated immunoglobulins (PAIg) IgG, IgM, IgA and complement C3c were related to parameters of 111 Indium‐labelled platelet kinetics in 17 patients with chronic idiopathic autoimmune thrombocytopenia (cAITP). Elevated levels of PAIg/C3c were found in 14 patients (82%) (PAIgG n = 13, PAIgM n = 11, PAIgA n = 1, PAC3c n = 5). Only PAIgG correlated with platelet counts (R s = ‐0.71, p < 0.01). Mean platelet life span (MLS) was shortened in all patients (median 12.0 h, range 0.3–45.6 h) and correlated with the platelet counts (R s = 0.49, p < 0.05). MLS was correlated with PAIgG (R s = ‐0.52, p < 0.05), but not with PAIgM, PAIgA, or PAC3c. The site of sequestration was splenic in 10 patients and splenic‐hepatic in 7 patients. Although no significant correlation between either site of platelet sequestration and any of the investigated PAIg/C3c was demonstrable, platelets coated with higher PAIgG levels were more readily sequestrated in the spleen, while elevations of PAC3c were found in 4 out of 7 patients with hepatic involvement.