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Hypoxanthine and xanthine in stored SAGM‐blood
Author(s) -
Andersen Per Thorgaard,
Bacher Theis,
Stentoft Jesper
Publication year - 1986
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1986.tb01772.x
Subject(s) - hypoxanthine , xanthine , purine , purine metabolism , chemistry , biochemistry , chromatography , enzyme
The concentration of xanthine and hypoxanthine was measured in 8 portions of SAGM red cell concentrates during 4 wk storage. The concentration of xanthine increased from 4.2 to 35.1 umol/l and the concentration of hypoxanthine increased from 16.8 to 165.2 μmol/l (mean values). Previous studies have demonstrated several important effects of purine bases ‐ among these a reduced cytotoxicity of purine antimetabolites. It is concluded that further studies are necessary to investigate the clinical role of purines in stored blood products.