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The effects of different doses of some acetylsalicylic acid formulations on platelet function and bleeding times in healthy subjects
Author(s) -
McLeod L. J.,
Roberts M. S.,
Cossum P. A.,
Vial J. H.
Publication year - 1986
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1986.tb01753.x
Subject(s) - platelet , bleeding time , medicine , thrombosis , platelet aggregation , aspirin , pharmacology , gastroenterology
In an attempt to find the most appropriate dose and formulation(s) of acetylsalicylic acid (ASA) for thrombosis prophylaxis, healthy volunteers were given doses of ASA for 1 wk daily ranging from 50 to 3900 mg as either Aspro‐Clear (soluble), Astrix (enteric coated pellets) or Ecotrin (enteric coated tablets). Platelet function and bleeding times were monitored. All doses of ASA significantly inhibited platelet function (p < 0.05) and increased bleeding times (p < 0.05) relative to control values. Irrespective of the formulation, maximum increases in bleeding time and platelet dysfunction were obtained with daily doses of about 100 mg, and no further changes were observed with higher doses.