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Megakaryoblastic leukaemia and myelofibrosis complicating Fanconi anaemia
Author(s) -
Dharmasena F.,
Catchpole M.,
Erber W.,
Mason D.,
GordonSmith E. C.
Publication year - 1986
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1986.tb01739.x
Subject(s) - pancytopenia , myelofibrosis , bone marrow , medicine , population , trephine , fanconi anemia , pathology , biology , dna , environmental health , dna repair , genetics
A 9‐yr‐old boy with a 2‐yr history of Fanconi anacmia developed worsening pancytopenia that was unresponsive to oxymetholone therapy. Bone marrow was difficult to aspirate but showed the presence of megakaryoblasts. Bone marrow trephine was hypercellular with large clusters of abnormal megakaryocytes and a small population of megakaryoblasts, giving a diagnosis of megakaryoblastic leukaemia.