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Red pulp in splenomegaly syndrome: Morphometric light and electron microscopy studies
Author(s) -
Jensen O. Myhre,
Kristensen Jørgen
Publication year - 1986
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1986.tb01733.x
Subject(s) - hereditary spherocytosis , red pulp , pathology , hairy cell , spherocytosis , red cell , myeloproliferative disorders , medicine , bone marrow , lymphoproliferative disorders , spleen , immunology , splenectomy , hairy cell leukemia , leukemia , lymphoma
From a series of consecutively studied spleens, perfusion‐fixed and investigated according to a standardized procedure allowing morphometric investigations at the light and electron microscopic levels, 33 spleens causing splenomegaly syndrome (12 lymphoproliferative diseases, 10 hairy cell leukaemia, 11 myeloproliferative diseases) were compared with data in controls and autoimmune haemolytic anaemia and hereditary spherocytosis from previous studies. In splenomegaly syndrome, especially in hairy cell leukaemia and myeloproliferative diseases, less so in lymphoproliferative diseases, there is a disproportionate increase in the volume of pulp cords in the red pulp. Values for erythrocyte volume density are of the same order as splenic erythrocyte concentration determined by scintigraphic kinetic methods. Cases with complicating immunohaemolysis show a rather high proportion of erythrocyte profiles with nearly spheric shape as in autoimmune haemolytic anaemia and hereditary spherocytosis.