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Preleukaemia: A long‐term prospective study of 326 patients
Author(s) -
Todd William M.,
Pierre Robert V.
Publication year - 1986
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1986.tb00855.x
Subject(s) - cytopenia , medicine , chronic myelomonocytic leukemia , prospective cohort study , gastroenterology , bone marrow , karyotype , oncology , myelodysplastic syndromes , chromosome , biology , gene , genetics
Prospective bone marrow chromosome studies were done on 326 patients who met the criteria for the preleukaemic syndrome. Seventy‐two patients (22 %) had progression to overt acute nonlymphocytic leukaemia (ANLL). Of the original patients, 264 were retrospectively reclassified according to the French‐American‐British (FAB) dysmyelo‐poietic classification as follows: refractory cytopenia (RC), 23 patients; refractory anaeemia (RA), 126; RA with ringed sideroblasts (RARS), 56; RA with excess blasts (RAEB), 27; chronic myelomonocytic leukaemia (CMML), 29; and RAEB in transformation (RAEBIT), 3. The survival of patients with RC or RA was significantly better than that of patients with RARS, RAEB, or CMML. The differences in survival among patients with RARS, RAEB, or CMML were not significant. The survival of patients within each FAB classification was better in patients who had normal chromosomes. The presence of cytogenetic abnormalities was predictive of shorter survival and a higher frequency of progression to overt ANLL.