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Homogeneously staining chromosomal region in a case of erythroleukaemia
Author(s) -
Kovacs G.,
Freund M.,
Poliwoda H.,
Leithauser H.,
Thiel E.
Publication year - 1986
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1986.tb00834.x
Subject(s) - staining , karyotype , biology , chromosome , bone marrow , microbiology and biotechnology , dna , marker chromosome , aneuploidy , peripheral blood , genetics , pathology , immunology , gene , medicine
Cytogenetical analysis of bone marrow and peripheral blood cells in a case of erythroleukaemia revealed a complex karyotype with a stemline of 44 chromosomes. I marker chromosome bearing a homogeneously staining region ( hsr ) was found in each of the aneuploid cells examined. The hsr was localised to the chromosome regions 15q12 and 15p12. The possible function of amplified DNA sequences and the relationship of hsr to cell proliferation are discussed.