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Evolution of a terminal deoxynucleotidyl transferase‐positive lymphoma from a chronic T cell lymphocytosis
Author(s) -
Oscier D. G.,
Mufti G. J.,
Hamblin T. J.,
Jones D. B.,
Smith J. L.
Publication year - 1986
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1986.tb00832.x
Subject(s) - lymphocytosis , hepatosplenomegaly , terminal deoxynucleotidyl transferase , pathology , medicine , atypical lymphocyte , spleen , lymphoma , leukocytosis , lymphoproliferative disorders , immunology , immunohistochemistry , disease , tunel assay
A 56‐yr‐old Caucasian man presented with a generalised scaly rash and a peripheral blood lymphocytosis of 5.6 times 10 9 /l. 5 yr later he developed cutaneous nodules, lymphadenopathy and hepatosplenomegaly. Cells with convoluted nuclei and prominent nucleoli were seen in the peripheral blood. He underwent splenectomy and received intensive chemotherapy but died 6 months later with CNS infiltration. At presentation the peripheral blood lymphocytes were E‐ve, UCHT1 + ve, and OKT8 + ve. Following transformation, cells in blood, spleen and CSF were E‐ve, OKT11 + ve, DR + ve and Tdt + ve. A proportion of these cells had a Sézary‐like appearance at E/M. The splenic cells showed functional suppressor activity. This is the first reported case of the evolution of a Tdt + ve lymphoma from a post‐thymic T cell lymphocytosis.