Premium
HTLV‐III seropositivity in symptom‐free Italian haemophiliacs. Correlation with consumption of commercial concentrate and abnormalities of T and B lymphocytes
Author(s) -
Giudizi M. G.,
Biagiotti R.,
Almerigogna F.,
Mazzetti M.,
Alessi A.,
Massai G.,
Longo G.,
Scano G.,
Morfini M.,
Romagnani S.
Publication year - 1986
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1986.tb00828.x
Subject(s) - antibody , immunology , in vitro , medicine , t cell , chemistry , immune system , biochemistry
Various immunological parameters exploring both T‐ and B‐cell functions were determined in a group of 74 symptom‐free Italian haemophiliacs treated with commercial concentrate imported from the USA and were correlated with the presence in their serum of antibody to HTLV‐III. There was a strong correlation between HTLV‐III seropositivity and the amount of concentrate consumed. A significant correlation between HTLV‐III seropositivity and T‐cell alterations, such as T4/T8 ratio less than 1 and reduction in the absolute number of T4 + lymphocytes, or B‐cell alterations such as hypergammaglobulinaemia and enhanced spontaneous IgG synthesis in vitro, was also observed.