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Successful treatment of acute megakaryoblastic leukaemia
Author(s) -
Ninomiya Haruhiko,
Nakazawa Masaki,
Shibuya Akira,
Aoki Yasuko,
Nagasawa Toshiro,
Abe Tsukasa
Publication year - 1986
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1986.tb00819.x
Subject(s) - aclarubicin , anthracycline , medicine , cytosine , complete remission , gastroenterology , hydrochloride , mercaptopurine , chemotherapy , chemistry , dna , biochemistry , organic chemistry , cancer , breast cancer
2 patients with acute megakaryoblastic leukaemia (AMKBL) were successfully treated with a combination of aclarubicin hydrochloride (an anthracyline), enocitabine (a derivative of cytosine arabinoside) and 6‐mercaptopurine (6‐MP) or 6‐thioguanine (6‐TG). They achieved a complete remission following 1 or 2 courses. They remained well and in complete remission throughout 3 courses of consolidation therapy, a total of 9 weeks. The results of remission induction therapy of AMKBL have been reviewed in the literature. 4 of 7 adult patients, including our cases, treated with 3 drugs, anthracycline, cytosine arabinoside or its derivative and 6‐TG or 6‐MP, achieved a complete remission. AMKBL may not have so poor a prognosis as previously believed.