Premium
Erythrocyte involvement in chronic lymphocytic leukaemia
Author(s) -
Meyerstein N.,
Oppenheim U.,
Yirmiahu T.,
Hatskelson L.,
Dvilansky A.
Publication year - 1986
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1986.tb00817.x
Subject(s) - chronic lymphocytic leukemia , lymphoproliferative disorders , immunology , medicine , lymphoproliferative disease , coombs test , leukemia , antibody , lymphoma
Chronic lymphocytic leukaemia (CLL) is a lymphoproliferative disorder which sometimes also affects the erythrocytes. In this study we investigated erythrocyte involvement in 23 CLL patients. We found increased erythrocyte osmotic fragility in 15 CLL patients, but this finding was not accompanied by increased permeability to acidified glycerol (decreased AGLT 50 ). Only those CLL patient who had positive direct antiglobulin test (DAT) had significantly decreased AGLT 50 . AGLT cannot serve as a predictor test for the future development of autoimmune haemolytic anaemia in CLL patients. ATP content was unaffected by the lymphoproliferative disease, but whole blood filterability was markedly decreased in CLL patients. Our study supports the hypothesis that erythrocytes are indeed affected by the lymphoproliferative disorder, even in the absence of overt autoimmune haemolytic processes.