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Primary plasma cell leukaemia: immunological and ultrastructural studies in 6 cases
Author(s) -
Parreira A.,
Robinson D. S. F.,
Melo J. V.,
Ayliffe M.,
Ball S.,
Hegde U.,
Baughan A.,
Fairhead S.,
Talavera J. G.,
Katzmann J. A.,
Catovsky D.
Publication year - 1985
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1985.tb02830.x
Subject(s) - ultrastructure , pathology , plasma cell , cytoplasm , cell , antigen , chemistry , biology , microbiology and biotechnology , immunology , antibody , medicine , biochemistry
The clinical and laboratory studies of 6 patients with primary plasma cell leukaemia are described. The leukaemic cells had a variable morphology, ranging from lymphoplasmacytic and mature plasma cells to poorly differentiated blasts. The neoplastic plasma cells had a characteristic phenotype: they were positive for CyIg and the McAb OKT10 and Ri‐3, and did not express the B‐cell antigens Ia, B1 and B4. Ultrastructural studies confirmed the plasma cell nature of the leukaemic cells and showed the presence of a meshwork of cytoplasmic fibrils in 50 to 90% of the neoplastic cells from all cases. The distinct ultrastructural and immunological features of PCL described in this study will help the diagnosis and further characterisation of this disease entity.