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Association of Gaucher's Disease and lymphoid malignancy in 2 children
Author(s) -
Burstein Y.,
Rechavi G.,
Rausen A. R.,
Frisch B.,
Spirer Z.
Publication year - 1985
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1985.tb02269.x
Subject(s) - glucocerebroside , immune system , malignancy , disease , medicine , immunology , cell , pathology , biology , glucocerebrosidase , genetics
2 cases of acute lymphoblastic leukaemia (ALL) of childhood in association with Gaucher's Disease (GD) are presented, which are the first to be described. One of them is a common non‐B non‐T cell ALL and the other is at T‐cell ALL. The association of GD with benign and malignant B‐cell proliferation has recently been described. It is suggested that chronic stimulation of the immune system by the accumulated glucocerebroside may predispose to B cell proliferation.