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Plasma cobalamin‐binding and serum cobalamin in patients with folate deficiency
Author(s) -
Lewis M.J.,
Dawson D.W.
Publication year - 1985
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1985.tb02255.x
Subject(s) - cobalamin , medicine , vitamin b12 , cyanocobalamin , endocrinology , pernicious anaemia , chemistry , in vivo , biology , microbiology and biotechnology
Plasma unsaturated R‐binder and transcobalamin 2 (TC 2) levels were measured in 62 patients with folate deficiency and compared with 80 control subjects and 52 patients with pernicious anaemia. An increase in unsaturated R‐binder concentration was found in the majority of patients with folate deficiency and with PA. In folate deficiency, however, the unsaturated R‐binder was often elevated whether the serum cobalamin (Cbl) was low or normal, more frequently when the serum Cbl was normal. Results of a separate in vivo study of plasma retention of injected 57 Co cyanocobalamin were consistent with these findings. An elevated TC 2 was found in a small number of patients with folate deficiency and with PA. The serum Cbl appears to the maintained at a normal level in some patients with folate deficiency by an increase in R‐binder, which is caused by folate deficiency itself.