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Chronic T cell lymphocytosis with large granular lymphocytes of helper (OKT4) phennoype
Author(s) -
Berrebi Alain,
Talmor Monica,
Vorst Eljakim J.,
Shtalrid Mordechai,
Polliack Aaron,
Nir Emanuel
Publication year - 1985
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1985.tb02250.x
Subject(s) - lymphocytosis , asymptomatic , immunology , t cell , stimulation , biology , pathology , chemistry , medicine , microbiology and biotechnology , immune system , endocrinology
A 54‐year‐old asymptomatic male patient was followed for more than 7 y and presented a constant T cell lymphocytosis without skin involvement or bone marrow depression. No clinical or haematological aggravation was noted during this follow‐up. Morphologically, the cells were large granular lymphocytes strongly positive for beta‐D‐glucuronidase, negative for acid phosphatase and with features of T cells on transmission and scanning electron microscopy. The immunological studies of the lymphocytes showed the following parameters: E rosettes+, mouse rosettes‐, SmIg‐, OKT3+, OKT4 +, OKT8‐, OKT6‐, Ia‐, TdT‐, NK‐, HTLV‐, decreased PHA and PWM stimulation, no interleukin 2 production and failure to enhance Ig synthesis in a PWM driven system. The karyotype was normal. This case of chronic T cell lymphocytosis with large granular lymphocytes helper profile and defect of helper function, not reported in the literature, may correspond to a distinct entity in the heterogeneous group of chronic T cell disorders.