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Treatment of severe chronic idiopathic thrombocytopenic purpura in adults with high‐dose intravenous gammaglobulin
Author(s) -
Korninger C.,
Panzer S.,
Graninger W.,
Neumann E.,
Niessner H.,
Lechner K.,
Deutsch E.
Publication year - 1985
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1985.tb02244.x
Subject(s) - medicine , platelet , gamma globulin , thrombocytopenic purpura , antibody , gastroenterology , purpura (gastropod) , immunoglobulin g , intravenous immunoglobulin therapy , immunology , ecology , biology
12 patients with severe chronic idiopathic thrombocytopenic purpura (ITP) were treated with i.v. polyvalent intact immunoglublin (0.14–0.4 g/kg body weight for 5 d) because of various bleeding episodes or prior to surgery. In 9 patients a significant rise in platelet counts was noted, starting on d 2 and reaching its maximum between d 4 and 11. Thereafter, platelet counts decreased slowly, approaching pre‐treatment values after 20 d in most cases. Response to immunoglobulin was reproducible, when infusions were repeated. Response to high‐dose immunoglobulin was independent of age of patients and duration of disease. Platelet‐associated IgG decreased in all patients tested. A pepsin‐treated immunoglublin preparation was ineffective in 3 patients.