Premium
A case of Burkitt lymphoma — L 3 ALL with t(8;14) translocation, developed 10 years after Hodgkin's disease
Author(s) -
Mandelli Franco,
Martelli Maurizio,
Cimino Giuseppe,
Alimena Giuliana,
Anselmo Anna Paola,
Cuia Maria Rosaria,
Gastaldi Roberta,
Arcese William,
Papa Giuseppe
Publication year - 1985
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1985.tb02240.x
Subject(s) - chromosomal translocation , lymphoma , autopsy , pathology , lymph , bone marrow , disease , medicine , burkitt's lymphoma , radiation therapy , biology , biochemistry , gene
We report the case of a 38‐year‐old man, previously treated for Hodgkin's disease (HD) with chemo‐radiotherapy who, 10 years later, developed a Burkitt lymphoma (BL) as a tumour mass of the ascendent colon and regional lymph nodes and, subsequently, on leukaemic bone‐marrow cells, on the basis of histological, immuno‐logical (B phenotype, IgM‐λ) and cytogenetic, translocation t(8;14) features. The patient died a few days later; at autopsy no evidence of HD was found. This is the 2nd case of BL developing after HD so far described. The relationship between the 2 diseases is discussed and the importance of the immunodepression in the pathogene‐sis of the secondary Burkitt lymphoma is emphasized.