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Lactate overproduction in platelets of subjects affected with myeloproliferative disorders
Author(s) -
Leoncini G.,
Maresca M.,
Armani U.,
Piana A.
Publication year - 1985
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1985.tb01579.x
Subject(s) - glycogen , glycogen phosphorylase , medicine , glycolysis , endocrinology , myeloproliferative disorders , platelet , glycogenolysis , chemistry , carbohydrate metabolism , biochemistry , metabolism , biology
In platelets of patients affected with myeloproliferative disorders, glycolytic and glycogenolytic flux have been examined. Results of studies on glucose uptake, glycogen breakdown and lactate formation have been reported. No difference in glucose uptake between controls and patients was observed, but in patients a higher lactate formation was always noted in the presence or absence of exogenous glucose, in correlation with a higher glycogen breakdown rate. Results could be explained by modified regulation mechanisms on glycogen phosphorylase.