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Acquired factor X and antithrombin III deficiency in a patient with primary amyloidosis and nephrotic syndrome
Author(s) -
Quitt Miriam,
Aghai Esther,
David Miriam,
Kohan Ricardo,
Ari Yaakov Ben,
Froom Paul
Publication year - 1985
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1985.tb01564.x
Subject(s) - nephrotic syndrome , medicine , amyloidosis , antithrombin , gastroenterology , al amyloidosis , immunology , heparin , antibody , immunoglobulin light chain
A 45‐year‐old man with primary amyloidosis was initially seen with nephrotic syndrome. Factor X was found to be 5% and antithrombin III (AT III) 45% of normal plasma values. During an 11‐month period, despite severe factor X deficiency, the patient did not have any bleeding complications. He developed progressive renal failure and AT III levels increased to normal, at which time he developed severe bleeding complications. These findings suggest a protective role of AT III deficiency against bleeding in a patient with severe factor X deficiency.