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Significance of multiple types of antibodies on red blood cells of patients with positive direct antiglobulin test: A study of monospecific antiglobulin reactions in 85 patients
Author(s) -
BenIzhak Cfer,
Shechter Yael,
Tatarsky Ilana
Publication year - 1985
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1985.tb00808.x
Subject(s) - haemolysis , coombs test , antibody , immunology , medicine , hemolysis
Blood samples from 85 patients with a positive direct antiglobulin test were tested with monospecific antiglobulin reagents: anti‐IgG, anti‐IgM, anti‐IgA, and anti‐C3. No typical pattern of antiglobulin reaction could be correlated with specific diseases except for the patients with methyldopa‐induced positive direct antiglobulin test, all of whom had only IgG on their red blood cells. The presence of more than 1 type of antibody on red blood cells was associated with severe haemolysis. These patients responded less frequently to steroids, and in most of them no underlying disease could be found. Most patients with complement alone on red blood cells had no evidence of haemolysis, and when present it was never severe.