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Alpha interferon treatment of patients with hairy‐cell leukaemia
Author(s) -
Hagberg Hans,
Alm Gunnar,
Björkholm Magnus,
Glimelius Bengt,
Killander Andreas,
Simonsson Bengt,
Sundström Christer,
Åhre Anders
Publication year - 1985
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1985.tb00802.x
Subject(s) - hairy cell , medicine , bone marrow , hairy cell leukemia , interferon , infiltration (hvac) , alpha interferon , cell , interferon alfa , peripheral blood , gastroenterology , immunology , leukemia , chemistry , biochemistry , physics , thermodynamics
We have treated 10 patients with hairy‐cell, or hairy‐cell‐like leukaemia, for more than 6 months, with alpha interferon 3 × 10 6 IV/day I.M. or subcutaneously. All patients were severly pancytopenic before treatment. 7 patients had a typical hairy‐cell leukaemia, whereas 3 lacked hairy cells but had the characteristic bone‐marrow infiltration. The peripheral blood counts improved in all patients during treatment and the lymphoid infiltration of the bone‐marrow was shown to decrease. 1 patient obtained complete remission, 6 partial remission and 3 had a minor response. It is concluded that alpha interferon is effective in the treatment of patients suffering from hairy‐cell leukaemia.