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Development of acute nonlymphocytic leukaemia (ANLL) in myelomatosis
Author(s) -
Drivsholm Aage,
Lisse Ida,
Philip Preben
Publication year - 1985
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1985.tb00796.x
Subject(s) - childhood leukaemia , multiple myeloma , medicine , leukemia , immunology , cancer research , pediatrics
On the basis of the literature, so‐called secondary acute nonlymphocytic leukaemia (S‐ANLL) in myelomatosis is reviewed. Using the banding technique, cytogenetic changes including hypodiploidy and partially or totally missing chromosomes # 5 and # 7 are recorded. The findings are in accordance with the cytogenetic changes seen in S‐ANLL in other malignancies which have been treated with cytostatics, especially alkylating agents. So, S‐ANLL in myelomatosis seems to be a result of treatment with cytostatics, though a causal relationship has to be documented.