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A Swedish family with abnormal antithrombin III
Author(s) -
Tengborn Lilian,
Frohm Birgitta,
Nilsson LarsErik,
Nilsson Inga Marie
Publication year - 1985
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1985.tb00770.x
Subject(s) - antithrombin , medicine , cardiology , heparin
An abnormal variant of antithrombin III is reported in a young male with deep vein thrombosis. The heparin cofactor, progressive thrombin inhibition, and factor Xa inactivation are decreased. The abnormality seems to be a mutation which is transmitted in an autosomaldominant way. The half‐life and fractional catabolic rate of 125 I antithrombin III concentrate is the same in this patient as in patients with the classic type of antithrombin III deficiency and in a control.