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Sézary syndrome: phenotypic and functional characterization of the neoplastic cells
Author(s) -
Ralfkiaer Elisabeth,
Wantzin Gunhild Lange,
Larsen Joergen K.,
Andersen Vagn,
Geisler Christian,
Plesner Torben,
Thomsen Kristian
Publication year - 1985
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1985.tb00766.x
Subject(s) - phenotype , biology , cancer research , genetics , immunology , pathology , medicine , gene
Phenotypic properties of the neoplastic cells in skin, blood and lymph node specimens from 5 patients with the Sézary syndrome were examined by immuno‐enzymatic and ‐fluorescence labelling of cells and tissue sections with a monoclonal antibody panel. In 3 cases, the in vitro functional properties of the neoplastic cells (isolated from blood specimens) were also analysed using a reverse plaque‐forming cell assay. 3 different immunological categories were identified as follows: (1) T‐helper/inducer neoplasms (3 patients); (2) T‐suppressor/cytotoxic neoplasms (1 patient); and (3) neoplastic T‐cells demonstrating characteristics consistent with a concept of their derivation from inducible suppressor T‐cells (1 patient). These data provide conclusive evidence that Sézary syndrome is heterogeneous with respect to the immunological characteristics of the neoplastic cells.