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Long‐term high dose factor VIII treatment of 3 haemophiliacs with factor VIII inhibitor
Author(s) -
Scheibel E.,
Feddersen C.,
Hertz H.
Publication year - 1985
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1985.tb00765.x
Subject(s) - term (time) , medicine , factor (programming language) , computer science , programming language , quantum mechanics , physics
3 patients with haemophilia A and inhibitor against Factor VIII were developing progressive haemophiliac arthropathy due to the non‐feasibility of prophylactic treatment. In order to suppress inhibitor formation, long‐term treatment with high‐dose Factor VIII (100 units per kg body weight twice daily) was initiated. Prothrombin complex concentate was given only for bleeding episodes. Though all 3 patients were high responders, they presented different treatment courses. 2 became low responders after 4 and 11 months' treatment, respectively. 1 patient had no demonstrable inhibitor after start of treatment. In all 3 patients, prophylactic treatment was established, in 1 case still with increased doses compared to non‐inhibitor patients. The high‐dose Factor VIII treatment makes in possible to provide prophylactic treatment for the high‐responder inhibitor patients. However, the extremely high costs represent a serious obstacle to this treatment.