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Serum immunosuppressive acidic protein in adult T‐cell leukaemia (ATL)
Author(s) -
Tagawa Shinichi,
Sawada Masumi,
Tokumine Yukihiro,
Ueda Etsuko,
Machii Takashi,
Hayashi Satoru,
Kurata Yoshiyuki,
Kitani Teruo
Publication year - 1985
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1985.tb00763.x
Subject(s) - antibody , medicine , gastroenterology , immunology
The availability of serum immunosuppressive acidic protein (IAP) as a marker of subtypes of adult T‐cell leukaemia (ATL) was examined. Serum IAP levels were measured in 34 patients with ATL (18 typical, 9 atypical and 7 smoldering), 7 healthy carriers of ATLA antibody and 53 healthy controls. The mean value of serum IAP was significantly higher in patients with typical ATL (897.8 + 502.4 μg/ml) than in those with atypical ATL (426.7 + 106.6 μg/l), smoldering ATL (310.0 + 51.3 μg/ml), healthy carriers of ATLA antibody (302.9 + 39.5 μg/ml) and normal controls (350.5 + 73.2 μg/ml). Serial determinations of IAP revealed that the level was correlated with the clinical course in patients with ATL; there was a difference in the prognosis of patients with high and normal levels of IAP ( P < 0.05). Thus, routine measurement of serum IAP seems useful in differentiating typical, atypical and smoldering ATL and also in evaluating the prognosis of patients.