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Factors and inhibitors of blood coagulation and fibrinolysis in acute nonlymphoblastic leukaemia
Author(s) -
Bratt G.,
Blombäck M.,
Paul C.,
Schulman S.,
Törnebohm E.,
Lockner D.
Publication year - 1985
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1985.tb00758.x
Subject(s) - medicine , fibrinolysis , fibrinogen , factor xiii , coagulation , gastroenterology , antithrombin , proteolytic enzymes , disseminated intravascular coagulation , coagulation testing , heparin , enzyme , biochemistry , chemistry
Factors of coagulation and fibrinolysis have been evaluated in 15 patients with untreated acute nonlymphoblastic leukaemia (ANLL). 10 patients had major bleeding (MB) and 6 had laboratory signs of DIC. 5 patients went into complete remission (CR). Antithrombin III (AT III) was decreased in 7 patients, antiplasmin (AP) in 9, fibronectin (FN) in 6 and factor XIII in 4/12. The ratio between factor VIIIR:Ag and factor VIII:C was over 2.0 in 11 patients, and high values were especially seen in patients with MB and patients with DIC. Spontaneous proteolytic activity, measured with S‐2288 was increased in 3 patients who all had MB, and none of whom achieved CR. 2 patients with promyelocytic leukaemia (M 3 ) had low fibrinogen and AP, high FDP and normal AT III, speaking for primary fibrinolysis, which in addition to proteolytic enzymes in the blast cells are important contributing factors regarding MB in ANLL.