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Kinetics and distribution in vivo of 111 In‐labelled autologous platelets in idiopathic thrombocytopenic purpura
Author(s) -
Schmidt Kai Gjerløff,
Rasmussen Jens Wæver
Publication year - 1985
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1985.tb00743.x
Subject(s) - platelet , in vivo , mean platelet volume , thrombocytopenic purpura , chemistry , spleen , kinetics , endocrinology , labelling , bone marrow , medicine , immunology , biochemistry , biology , physics , microbiology and biotechnology , quantum mechanics
The kinetics of autologous 111 In‐labelled platelets were studied in 26 patients with ITP. The platelet mean life time (MLT) was considerably shortened, the platelet in vivo recovery slightly lowered and the platelet turnover normal. Comparative studies of the kinetics of simultaneously injected 111 In‐ and 51 Cr‐labelled platelets in 10 patients showed the MLT and turnover of 51 Cr‐platelets to be shorter and higher, respectively, than those of 111 In‐platelets, suggesting that 51 Cr‐labelling in ITP may underestimate platelet MLT and overestimate platelet turnover. Our results confirm that accelerated platelet destruction is an important pathogenetic factor in ITP, and that the platelet concentration may be influenced by increased splenic platelet pooling and by inability of the bone marrow to respond adequately to the low platelet count. Our scintigraphic studies showed that the spleen played an important role for platelet destruction in most patients, with the liver contributing in some patients.