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Kinetic evaluation of four Factor VIII concentrates by model‐independent methods
Author(s) -
Matucci M.,
Messori A.,
DonatiCori G.,
Longo G.,
Vannini S.,
Morfini M.,
Tendi E.,
RossiFerrini P. L.
Publication year - 1985
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1985.tb00739.x
Subject(s) - factor (programming language) , statistics , mathematics , computer science , programming language
Single‐dose kinetics of 4 Factor VIII concentrates (Kryobulin, Hemofil T, Koate, cryoprecipitate) were studied in 41 patients with haemophilia‐A. Model‐independent methods were adopted for calculating the kinetic parameters (area under the curve, clearance, area under the moment curve, mean residence time, volume of distribution at steady‐state). No substantial difference was observed in the kinetic characteristics of the 4 Factor VIII concentrates. A considerable interindividual variability of the calculated kinetic parameters was demonstrated for all concentrates. Our findings support the need to individualize Factor VIII dosage.