Premium
Von Willebrand's Disease: State of the Art
Author(s) -
Bowie E J W
Publication year - 1984
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1984.tb02596.x
Subject(s) - cryoprecipitate , von willebrand disease , von willebrand factor , disease , abnormality , medicine , immunology , pediatrics , psychiatry , fibrinogen , platelet
Von Willebrand's disease is a familial bleeding disorder affecting both sexes and is due to the absence, decrease or abnormality of a plasma protein — the von Willebrand factor. This white paper on the disease was prepared by an international committee of the World Federation of Hemophilia. The clinical features of the disease are discussed and the nomenclature of the factor VIII complex is presented. The variant forms of the disease are classified and there is a detailed discussion of the problems in diagnosis. Finally, an approach to treatment is outlined including use of cryoprecipitate and DDAVP.