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Alteration of T Lymphocyte subpopulations in Swedish Hemophiliacs
Author(s) -
Biberfeld G,
Blombäck M,
Egberg N,
Lenkei R,
Nilsson I M,
PorwitKsiazek A
Publication year - 1984
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1984.tb02590.x
Subject(s) - medicine , factor ix , risk factor , lymphocyte , immunology , pediatrics , gastroenterology
T cell subpopulations were determined in 88 Swedish patients with severe hemostatic disorders treated with domestic or imported American factor VIII or Swedish factor IX preparations at two centres, Karolinska hospital (KH) and Malmö hospital (MH). Among the patients with severe hemophilia A from KH, all of whom had received American factor VIII concentrate, a decreased T helper/T suppressor (Leu 3/Leu 2) cell ratio (below 0.8) was found more frequently in adults (8 of 10) than in children (1 of 10). In the study of patients from MH, 15 of 18 adults and 4 of 8 children with severe hemophilia A, who had been treated with American factor VIII concentrate, had a decreased Leu 3/Leu 2 cell ratio. Decreased T cell ratios occurred also in hemophiliacs treated only with concentrates of Swedish origin. Thus 3 of 5 adults and 1 of 10 children with severe hemophilia A treated with Swedish factor VIII preparations (usually fraction 1‐0) as well as 2 of 8 adult hemophilia B cases treated with Swedish factor IX concentrate had a ratio below 0.8. There was no relationship between the T cell ratio and the amount of factor VIII of American or Swedish origin (expressed in units per kg and year) received during the previous two years.