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An Immunologic Study of Spouses and Siblings of Asymptomatic Hemophiliacs
Author(s) -
Ragni M V,
Bontempo F A,
Lewis J H,
Spero J A,
Rabin B S
Publication year - 1984
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1984.tb02588.x
Subject(s) - spouse , medicine , asymptomatic , sibling , immunology , immune system , psychology , developmental psychology , sociology , anthropology
A transmissable agent may be responsible for the recent occurrence of the acquired immune deficiency syndrome (AIDS) in female heterosexual partners and infant contacts of AIDS victims or of persons at increased risk for AIDS. We, therefore, evaluated the clinical and immunologic status of 18 hemophiliac‐spouse pairs and 19 hemophiliac‐sibling pairs. Using surface marker assays of lymphocyte subpopulations, we found a mean T helper cell/T suppressor cell (H/S) ratio ± S.E.M. in 18 hemophiliac adults of 1.11 ± 0.15 (eleven <1.00), in their 18 spouses of 1.88 ± 0.13 (none <1.00), in 19 hemophiliac children of 1.54 ± 0.11 (three(<1.00), and in their 19 siblings of 1.87 ±0.11 (none< 1.00). Both hemophiliac adult and hemophiliac children mean H/S ratios differed significantly (p < 0.05) from the control mean ratio of 2.22 ± 0.16 and from the mean of their respective non‐hemophiliac spouse or sibling group (p < 0.05). The mean ratio of hemophiliac adults differed significantly from that of hemophiliac children (p < 0.05). These findings suggest that lymphocyte alterations in hemophiliacs are secondary to their therapy, are not influenced by genetic factors, and are not related to an infectious agent that is easily transmissable by close contact.