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Decreased Helper‐Suppressor Cell Ratios Following Treatment with Blood Products: Factor VIII and IX Concentrates and Fresh Frozen Plasma
Author(s) -
Ragni M V,
Lewis J H,
Spero J A,
Bontempo F A,
Rabin B S
Publication year - 1984
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1984.tb02587.x
Subject(s) - asymptomatic , medicine , factor ix , group a , gastroenterology , immunology , risk factor , group b , fresh frozen plasma , platelet
The immunologic status of three groups of multiply‐transfused asymptomatic patients was evaluated. These included five with acquired inhibitors to factor VIIi treated with both factor VIII and factor IX concentrates (group A), seven with hemophilia B treated with factor IX concentrate (group B), and six with hemophilia B treated with fresh frozen plasma (group C). Mean T helper/T suppressor cell ratios (± S.E.M.) for the three groups were 0.72 ± 0.09, 1.35 ± 0.18 and 1.37 ± 0.12, respectively. All three differed significantly (p < 0.01) from the control mean ratio of 2.22 ± 0.16. In addition the mean ratio of group A patients was significantly different (p < 0.01) from that of groups B and C. An inverted ratio (< 1.00) was found in all group A patients and only one group B patient. An elevated IgG was found in 80 percent, 57 percent and 5 0 percent of each group, respectively. These immunological findings bear a striking resemblance to those of the acquired immunodeficiency syndrome (AIDS) of homosexuals, intravenous‐drug abusers, Haitian immigrants, and factor‐VIII‐concentrate‐treated hemophiliacs. Transmission via a blood borne infectious agent seems likely.