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High dose intravenous gammaglobulin and platelet transfusions in leukaemic HLA‐immunized patients
Author(s) -
Bierling P.,
Cordonnier C.,
Rodet M.,
Vernant J. P.,
Pesce A.,
Rochant H.,
Duedari N.
Publication year - 1984
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1984.tb02399.x
Subject(s) - platelet , gamma globulin , medicine , refractory (planetary science) , platelet transfusion , immunology , human leukocyte antigen , gastroenterology , antigen , antibody , biology , astrobiology
3 aplastic patients with acute leukaemia, strongly HLA‐immunized and refractory to platelet transfusions, received polyvalent gammaglobulin i.v. infusions (0.4 g/kg/d for 5 or 6 d) in association with daily random platelet transfusions. Platelet recovery was obtained in 2 patients. The 3rd patient did not show any significant rise in platelet count. The ability of gammaglobulin to prolong the life‐span of incompatible transfused platelets could facilitate the management of HLA‐immunized patients.