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Acquired factor VIII:C inhibitor (IgG) and positive direct Coombs' test (IgM) in a patient with lung carcinoma
Author(s) -
Cataldo F.,
Baudo F.,
Redaelli R.,
Pezzetti L.
Publication year - 1984
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1984.tb02392.x
Subject(s) - prednisone , medicine , coombs test , cyclophosphamide , carcinoma , squamous cell carcinoma of the lung , gastroenterology , basal cell , lung , antibody , immunology , chemotherapy
A 73‐year‐old man with lung squamous‐cell carcinoma simultaneously developed a factor VIII:C inhibitor and a transient positive direct Coombs' test. The factor VIII:C inhibitor was characterized as a mixture of IgG 1 , IgG 2 , IgG 4 with χ and Λ light chains. The Coombs' test was IgM‐specific. Treatment: blood transfusions (packed red cells), cyclophosphamide and prednisone. Bleeding subsided without factor VIII‐replacement therapy. Before death, in spite of the tumour‐mass progression, factor VIII:C was normal.