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Cytogenetic findings in acute promyelocytic leukaemia A report of 25 cases
Author(s) -
Alimena G.,
Dallapiccola B.,
Cuia M. R.,
Gallo E.,
Gastaldi R.,
Nanni M.,
Franchi A.,
Mandelli F.
Publication year - 1984
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1984.tb02388.x
Subject(s) - chromosomal translocation , karyotype , bone marrow , cytogenetics , chromosome , medicine , acute promyelocytic leukemia , gastroenterology , pathology , biology , genetics , cell culture , gene , retinoic acid
Cytogenetic analyses of bone marrow cells were carried out by means of direct technique and short‐term cultures in 25 acute promyelocytic leukaemia (APL) patients. 16 were affected by the hypergranular form and 9 by the M 3 ‐variant. The t(15;17) was documented at diagnosis in 15 patients. In addition, 2 cases, in which an M 3 morphology and a normal karyotype on direct preparation were found at diagnosis, disclosed the chromosome anomaly in cultured cells at relapse, in concomitance with a change of blast morphology to the M 3 ‐variant. However, the t(15;17) was a consistent feature in 5 of the 15 patients with cells analysed on direct preparations only and in all cases who had successful bone marrow cultures. Overall, the 15;17 translocation was detected in 7 out of 9 patients with the M 3 ‐variant and in 8 out of 16 patients with typical M 3 . Whenever the chromosome preparations were made after culture, 7/7 had the translocation in the M 3 ‐V group and 5/5 in the M 3 group. No obvious differences in clinical features or outcome were evident in the patients, irrespective of their cytogenetic findings.