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Iron overload and lysosomal stability in β°‐thalassaemia intermedia and trait: Correlation between serum ferritin and serum N‐acetyl‐β‐D‐glucosaminidase levels
Author(s) -
Frigerio R.,
Mela Q.,
Passiu G.,
Cacace E.,
Nasa G.,
Perpignano G.,
Carcassi U. E. F.
Publication year - 1984
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1984.tb02224.x
Subject(s) - ferritin , serum ferritin , medicine , endocrinology , chemistry , beta (programming language) , serum iron , immunology , anemia , computer science , programming language
Increased iron storage represents a characteristic condition in patients with β‐thalassaemia intermedia. Iron overload is an important factor in cellular damage. Recent studies have shown an enhanced lysosomal fragility due to increased iron storage. 13 patients with β°‐thalassaemia intermedia, aged 17–44 years, were studied. Both serum ferritin and serum N‐acetyl‐β‐D‐glusosaminidase levels were evaluated in all subjects studied. A significant linear correlation ( P < 0.05) between serum ferritin and serum N‐acetyl‐β‐D‐glucosaminidase levels were found.