Premium
Decrease of Fcγ and C3b receptor‐bearing granulocytes and of T lymphocytes in myelomatosis
Author(s) -
Næss A.,
Hopen G.,
Solberg C. O.
Publication year - 1984
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1984.tb02215.x
Subject(s) - incubation , receptor , fc receptor , immunology , chemistry , granulocyte , medicine , biochemistry
18 patients with myelomatosis had lower percentages of granulocytes bearing receptors for Fcγ (47.6%) and C3b (43.0%) than controls (80.4% and 75.0%). The percentage of T lymphocytes was decreased in patients when untreated sheep erythrocytes were used as indicator cells. Patients with high serum IgG levels had lower percentages of T lymphocytes. There was no significant difference in receptor profile between treated and untreated patients. The decrease in Fcγ and C3b receptor‐bearing granulocytes in myelomatosis is probably not due to serum or plasma factors since (a) the distribution of receptor‐bearing lymphocytes was not different from that of the controls; (b) extra washings of cells or overnight incubation did not enhance the percentage of receptor positive cells; and (c) incubation of normal granulocytes in sera or plasma from myelomatosis patients did not cause a more pronounced reduction in the proportions of Fcγ of C3b receptor‐bearing cells than incubation in normal sera or plasma.