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Defective intrinsic fibrinolytic activity in a patient with severe factor XII‐deficiency and myocardial infarction
Author(s) -
Lodi Sergio,
Isa Luciano,
Pollini Ettore,
Bravo Alberto Ferrari,
Scalvini Augusto
Publication year - 1984
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1984.tb02214.x
Subject(s) - fibrinolysis , factor xii , myocardial infarction , medicine , coagulation , cardiology , endocrinology
The paper reports the occurrence of myocardial infarctions in a patient with severe deficiency of blood coagulation factor XII (Hageman factor). Factor XII plays a central role in the intrinsic activation of fibrinolysis and consequently the defective intrinsic fibrinolytic activity detected in the present case casts some doubt on its role in the increased vulnerability to thrombotic accident.