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Biochemical markers in non‐Hodgkin's lymphoma stages III and IV and prognosis: A multivariate analysis
Author(s) -
Hagberg H.,
Glimelius B.,
Gronowitz S.,
Killander A.,
Källander C.,
Schröder T.
Publication year - 1984
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1984.tb02211.x
Subject(s) - histopathology , medicine , lymphoma , multivariate analysis , beta 2 microglobulin , erythrocyte sedimentation rate , univariate analysis , gastroenterology , proportional hazards model , malignancy , pathology
The prognostic value of different pretreatment laboratory and clinical findings at diagnosis was assessed in a series of 141 patients with generalized non‐Hodgkin's lymphoma. Univariate and multivariate survival analysis (Cox's regression model) was performed, using serum analysis of deoxythymidine kinase (S‐TK), β 2 ‐microglobulin, lactic dehydrogenase, α 1 ‐acid glycoprotein = orosmucoid (S‐α 1 AGP), haptoglobin and ferritin. In addition, Hb and the erythrocyte sedimentation rate (ESR) were measured. The clinical variables were age, presence or absence of B‐symptoms, histopathology (‘low‐grade’; ‘intermediate grade’ and ‘high‐grade’ malignancy) and bone marrow involvement. Of the 8 biochemical markers, all except Hb and the ESR showed a significant relationship to survival. Among the clinical variables, this finding was made for B‐symptoms and histopathology. Using a multivariate analysis on all variables, S‐TK was found to be the best factor for predicting duration of survival. The only significant additional information was provided by S‐α 1 AGP. When only the clinical variables were taken into account, it was found that histopathology added significant information to that yielded by B‐symptoms in the prediction of the survival time. When the biochemical variables were added to this model, only S‐TK was of significant additional prognostic value.