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Heterogeneity of T‐Lymphocyte Chronic Lymphatic Leukaemia (CLL)
Author(s) -
Singh A. K.,
Lewis P.,
WetherleyMein G.
Publication year - 1984
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1984.tb02178.x
Subject(s) - monoclonal antibody , antigen , immunology , t cell , bone marrow , suppressor , medicine , t lymphocyte , antibody , monoclonal , lymphocyte , phenotype , peripheral blood , biology , immune system , cancer , gene , biochemistry
Lymphocyte surface markers (E‐SRBC, EAC, EAγ and SmIg) and monoclonal antibodies (OKT3, OKT4, OKT8 and OKIa) were used to characterise the blood and bone marrow lymphocytes of T‐cell CLL (8 patients). The diagnosis of T‐cell CLL was made primarily as the majority of blood lymphocytes formed E‐SRBC in ecah patient. Other markers – EAC, EAγ and SmIg – showed different patterns of association with E‐SRBC. These findings considered together described 4 different phenotypes amongst these patients: (a) E + (3 patients), (b) E + , EAC + (1 patient), (c) E + , EAγ + (2 patients), and (d) E + , SmIg + (2 patients). Similarly, 4 different groups were defined with the help of monoclonal antibodies. Helper T‐cell (3 patients) and suppressor T‐cell (1 patient) CLL showed predominantly helper T‐ and suppressor T‐lymphocytes respectively. Mixed T‐cell CLL (1 patient) comprised an equal proportion of both subpopulations, while the remaining 3 patients, with excess of one or other subpopulations along with a considerable proportion of Ia antigen‐bearing lymphocytes, formed the indeterminate cell type CLL.