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Platelet Cyclo‐Oxygenase Deficiency in a Japanese
Author(s) -
Nakanishi Kozo,
Hato Takaaki,
Imai Atsuko,
Kaneko Hitoshi,
Murakami Akira,
Kuwashima Keiichi,
Ikeda Kyoichi,
Fujita Shigeru,
Kobayashi Yuzuru,
Kaido Hidetoshi,
Kondo Masaru,
Hattori Akira
Publication year - 1984
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1984.tb02173.x
Subject(s) - platelet , arachidonic acid , platelet aggregation , inducer , chemistry , epinephrine , medicine , prostaglandin , oxygenase , biochemistry , endocrinology , biology , enzyme , gene
A case of platelet cyclo‐oxygenase deficiency in a Japanese was investigated. There was a marked decrease of aggregation with collagen and absence of aggregation with epinephrine and arachidonic acid. The platelet response to a labile aggregation stimulating substance (LASS) was normal. There was no biosynthesis of prostaglandin endoperoxides from arachidonate. The platelets, including granular volume, showed no ultrastructural abnormalities. The responses to various inducers of platelet aggregation, except for arachidonate, were different from the cases described by others. It is concluded that the defective platelet function, due to a deficiency of platelet cyclo‐oxygenase, is heterogeneous.