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Haemoglobin D Punjab Interaction with α thalassaemia and diagnosis by gene mapping
Author(s) -
TRENT R. J.,
HARRIS M. G.,
FLEMING P. J.,
WYATT K.,
HUGHES W. G.,
KRONENBERG H.
Publication year - 1984
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1984.tb01693.x
Subject(s) - gene , inheritance (genetic algorithm) , genetics , biology , globin , computational biology
A family which illustrates the inheritance of Hb D Punjab (a β globin chain variant) and α thalassaemia is described. Interaction between Hb D Punjab and α thalassaemia is observed since levels of Hb D vary according to the number of α globin genes deleted. The technique of gene mapping has been utilised in the current study to provide definitive evidence of α thalassaemia and also demonstrates a novel way to identify Hb D Punjab.