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Ph 1 positive blast crisis of chronic myeloid leukaemia exhibiting features characteristic of early T blasts
Author(s) -
Herrmann F.,
Komischke B.,
Kolecki P.,
Ludwig W. D.,
Sieber G.,
Teichmann H.,
Rühl H.
Publication year - 1984
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1984.tb00697.x
Subject(s) - myeloid , antigen , monoclonal antibody , precursor cell , blast crisis , chronic myeloid leukaemia , immunology , megakaryocyte , lineage (genetic) , phenotype , biology , haematopoiesis , microbiology and biotechnology , antibody , cell , stem cell , genetics , gene
Leukaemic cells from a patient in the blast crisis of chronic myeloid leukaemia were subjected to a surface marker analysis using a panel of monoclonal antibodies recognizing differentiation antigens of myeloid (MY7, MY906, VIM D5, MØ P9), erythroid (VIE G4), megakaryocyte (AN51), T‐lymphoid (WT1, 10.2, OKT3, OKT4, OKT6, OKT8, OKT11A) and B‐lymphoid cells (B1, B2, Y29/55), common ALL‐antigen (VILA1), non‐lineage‐ restricted antigens (OKT9, OKT10), monomorphic HLA‐DR determinants (7.2) as well as TdT. When the patient entered his first blast crisis, his blasts expressed a phenotype corresponding to an immature myeloid cell (7.2+, MY7+, My906+, VTM D5‐). Ph 1 ‐ chromosome‐positive blasts from this patient's first relapse had completely changed their surface marker characteristics: they had become TdT‐positive and exhibited surface features characteristic of early T blasts (WT1+, 10.2+, OKT9+, OKT10+, 7.2‐, OKT6‐). Together, these features provide evidence that myeloid cells may share a common precursor with T cells.