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Acute monoblastic leukaemia: Clinical, biological data and survival in 45 cases
Author(s) -
Janvier M.,
Tobelem G.,
Daniel M. T.,
Bernheim A.,
Marty M.,
Boiron M.
Publication year - 1984
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1984.tb00693.x
Subject(s) - medicine , medullary cavity , abnormality , chemotherapy , chromosome , complete remission , pathology , biology , biochemistry , psychiatry , gene
Between 1978 and 1980, 45 cases of acute monoblastic leukaemia have been diagnosed, treated and followed in our institute. Morphological diagnosis was performed according to the French‐American‐British classification. Tumoral syndrome (particularly extra‐medullary) and hyperleucocytosis were the most striking findings at the time of diagnosis. Cytogenetic analysis performed in 31 cases before treatment has showed that abnormality of the long arm of chromosome 11 seemed to be more frequently associated with the poorly differentiated cytological subtype M5 (a). Intensive chemotherapy with zorubicine and cytosine arabinoside led to complete remission in 75 % of the cases. Central nervous system prophylaxis appeared definitively useful in preventing meningeal relapse. Despite a prolongation of the median duration of complete remission which now reaches 12 months, the prognostic is still poor.