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Diabetes insipidus in preleukaemic phase of acute myeloid leukaemia in 2 patients with empty della turcica: A report of 2 cases
Author(s) -
Puolakka Kari,
Korhonen Timo,
Lahtinen Reino
Publication year - 1984
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1984.tb00689.x
Subject(s) - diabetes insipidus , medicine , sella turcica , myeloid leukaemia , autopsy , lesion , diabetes mellitus , pathology , surgery , pediatrics , endocrinology
2 patients with diabetes insipidus established in the preleukaemic phase of acute myeloid leukaemia are described. Both patients had probably coincidentally an empty sella turcica showed by a computerized tomography. In one of them, leukaemia developed secondary to a cytostatic therapy for a vesical cancer. In this patient, blast cells appeared in cerebrospinal fluid after the patients had become polyuric and later on autopsy findings showed a peripituitary leukaemic infiltrate. In the other patient, diabetes insipidus and the acute phase of leukaemia developed after a long period with a dysmyelopoietic syndrome. Hormonal tests suggested a hypothalamic injury in both patients due to a leukaemic infiltrate at least in the former of them. It is concluded that diabetes insipidus as a consequence of hypothalamic lesion may develop in the preleukaemic phase of acute myeloid leukaemia and become evident even before any other symptoms of leukaemia have manifested.